Friday, October 19, 2007

Male Infertility- Name That Sperm Disorder

Sperm info, paraphrased and condensed

Oligozoospermia - Low sperm count

Mild cases might be successful with IUI. More commonly, however, IVF or in severe cases ICSI, may be required.

Asthenozoospermia - Reduced motility and/or impaired progression.

When the number of swimming sperm is reduced or if the sperm aren't swimming effectively, fertility is reduced. When it is just the number of motile sperm that is low, IUI or IVF may be recommended as the motile sperm can be extracted from the ejaculate and concentrated in the laboratory. However, if the ability of the sperm to swim is severely impaired, the chances of fertilisation through IVF may also be low, so ICSI may be recommended.

Teratozoospermia - Raised levels of abnormal sperm

Abnormal sperm have a reduced capacity to fertilise eggs or form viable embryos. In cases of mild teratozoospermia, IVF may be the appropriate treatment. When the number of normal sperm is very low ICSI may be required.

Azoospermia - No sperm present in the ejaculate.

There are various reasons for complete absence of sperm in the ejaculate. There may be a blockage or it may be a partial or complete failure in sperm production in the testes.

In cases of a blockage it is usually possible for a urologist to surgically extract sperm from the epididymis or the testes by MESA or TESE and for the embryologist to use such sperm to achieve fertilization in the laboratory through ICSI.

***In cases where there is no sperm, an exploratory TESE can be done to see if sperm is being produced or not. Occasionally, although the ejaculate may not have any sperm, there may be small pockets of sperm production within the testis and if these can be extracted, the sperm can be used to achieve fertilization through ICSI. ***


Improving Sperm Quality


Supplements that may potentially improve sperm count/quality.
All supplements should be taken long term as the sperm production cycle is approximately 90 days long.

• Zinc – 30milligrams twice daily
Zinc deficiency has been linked with a reduced sperm count. Zinc, in combination with other nutritional supplements (folic acid) has also been shown to improve sperm motility. Zinc is found naturally in meat, wholegrain cereals, seafood, eggs and pulses.

• Selenium – 200micrograms daily
Selenium has been shown to improve sperm motility both on its own and in conjunction with vitamin E. Selenium is found naturally in meat, seafood, mushrooms, cereals and in particularly high levels in Brazil nuts.

• Vitamin E – 400milligrams twice daily
Vitamin E is an antioxidant which may protect sperm from damage. Vitamin E is found naturally in vegetable oils, nuts and green leafy vegetables.

• Folic acid – 5milligrams daily
Folate, of which folic acid is the synthetic form, is essential for sperm production. It has been shown that folic acid in conjunction with zinc can improve sperm count and motility. Folate is found naturally in green leafy vegetables, liver, yeast and fruits.

Lifestyle

Smoking
Smoking as little as 1 cigarette per day directly reduces the number and quality of sperm. Smoking in males has even been show to decrease the success rates of both IVF and ICSI, non-smoking couples are almost twice as successful as those where the male smoked >5 cigarettes/day.

Alcohol
Heavy drinking (>20 units/week) has been shown to double the time taken to achieve pregnancy. There is also evidence to suggest that heavy drinking in men can subsequently lead to higher miscarriage rates.

Occupational exposure to toxins
Exposure to solvents such as paint, lacquers, adhesives, degreasers, printing inks and laboratory solvents on a regular basis has been shown to cause reduced sperm count and quality.

Temperature
Heat affects sperm quality, therefore, regular hot baths, saunas, steam rooms should be best. Loose fitting underwear has also been suggested to avoid problems with overheating of the testes.

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Thursday, October 18, 2007

I'm Doing Everything Right, So How Come I'm Not Pregnant??!!

Aside from any infertility issues, this is why:

http://www.pbs.org/wgbh/nova/miracle/program.html

I'll post some statistics later

Is the Basal Body Temperature Chart Really Important?

Yes, it really is.

It is the only thing you can do at home to confirm that you ovulated. If you see a clearly biphasic chart, you can be reasonably sure some type of ovulation has occurred. The only other way to attempt to confirm ovulation would be ultrasound visualization or a serum progesterone (blood work).

Please see the previous post titled OPKs, BBT, CM/CP,Saliva Microscopes for additional information.

You can be doing all the other things-OPKs, fertility monitors, saliva microscope, saliva strips, standing on your head.......if you are not keeping a BBT, you will never know if your timing is correct (unless you are working with your MD/NP/MW and blood work/ultrasound). Some women ovulate 12 hours after a + OPK and some surge 48 hours after a +OPK.

Wednesday, October 17, 2007

Testing, testing , testing....

The horrible evil TWW........sigh.....how can I end it sooner? When can I TEST ALREADY!!??

And the answer is..........it all depends. Suck answer huh? Okay but here's why:

The embryo begins implanting anywhere from 4 - 12 days and it takes about 4 - 7 days to finish implanting. Although the conceptus starts secreting progesterone and estrogen at fertilization, it is the placenta itself that secretes the hCG. The placenta has to be attached (implanted) and vascular communication established before hCG from the placenta can be released into the mother's bloodstream. hCG is the hormone you're looking for when testing for pregnancy.

This is why some people can get a + HPT at 8 DPO and some not until 19 or so DPO, it depends on when implantation began and when it was complete.

I believe the statistics show that most implantation begins at 8 DPO and completes in about 6 days, which is why an HPT is 95% accurate at 14-15 DPO. This does not mean it is impossible to get a BFP after 15 DPO just more unlikely.

GENERALLY SPEAKING these are the most common beta levels ranges in pregnancy. Of course the level is not nearly as important as whether or not it is doubling every 2-3 days.
HCG level for single baby (mIU/ml or IU/L)

Week 3,
0 to 5

Week 4,
5 to 426

Week 5,
18 to 7340

Week 6,
1,080 to 56,500

Weeks 7 to 8,
7,650 to 229,000

Weeks 9 to 12,
25,700 to 288,000

Weeks 13 to 16,
13,300 to 254,000

Weeks 17 to 24,
4,060 to 165,400

Weeks 25 to birth of baby,
3,640 to 117,000

4 to 6 weeks after birth,
Less than 5

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More housekeeping

Sooooooo more people than I thought want to keep this blog open. I know there are folks that aren't going to be happy about that but, then again, I doubt anything would make those folks happy.

Happiness is a choice, you can not control your world and the things in it, all you can control is yourself and how you react to that which is around you. "Me, 2007"
The next informational post will have to wait until Little Bit is off to dance class because she wants me to play yahtzee.


As far as board trolls confronting me is concerned. I will respond in whatever way makes me feel better at the time. That does not mean everyone has to respond the same way or even understand the reasoning behind why I respond a certain way. It just means that I have to handle the situation the way I feel I need to. Thanks to everyone for your support.

Everyone contributes to this blog, it belongs to everyone.

Tuesday, October 16, 2007

OPKs, BBT, CM/CP, Saliva Microscopes.

The saliva microscope detects the estrogen surge that comes before (and triggers) the LH surge


Cervical changes, positive OPK, O pains can all be attributed to the LH surge, yes you can surge and not ovulate.


All of the things mentioned above give you cues that ovulation is coming but NOT that it has occurred. Only the BBT can give you that information (along with ultrasounds and serum progesterone levels)


Yes, your body can "gear up" to O, have all the symptoms ,and not O.


The only way you could be reasonably sure O occured would be to have a clearly Bi-phasic temperature chart (temp increase is due to the progesterone released by the corpus luteum after ovulation-no ovulation=no corpus luteum=no jump in progesterone=no jump in temp), an increase in serum progesterone from prior levels, or visualizing it on an ultrasound.


My OB said "you didn't ovulate" this month when he got my serum progesterone level back.....until he saw my obvious biphasic chart along with everything else and said "Clearly you did" and put me on progesterone supplementation.


Some other explanations could be that:
1) you ovulated but not effectively or with a "bad egg"
2) you ovulated but the egg did not fertilize for whatever reason (remember, even with perfect timing there's only a 20-25% chance each cycle)
3) you ovulated, fertilized, but did not implant
4) you ovulated, fertilized, implanted then miscarried.
5) you are really pregnant and it is just not showing up yet (doubtful but not impossible!)


I would say to go to your doc and get some lab work, try to find out why you haven't started yet, and start charting your temps to identify possible anovulatory cycles quickly and try to determine underlying cause and appropriate treatment.


Hope this helps and I hope you don't need any of it because you have a "hidden" BFP!

Sunday, October 14, 2007

I Highly Recommend.......

  1. The fertility course offered at fertility friend (link in the side bar). It has a lot of valuable information.
  2. Fertility Friend charting/symptom tracking
  3. Clear Blue Easy Fertility Monitor BUT only in conjunction with an ovulation predictor kit. The monitor only allows once a day testing and that just isn't "pin-pointed" enough for some.
  4. Clear Blue Easy Digital ovulation predictor kit. I use the "internet cheapy" OPKs until I know I'm close and then I switch to the digital OPK every 4 to 6 hours.
  5. Fertile Focus saliva microscope.
  6. Ovucheck disposable saliva strips.
  7. "Internet cheapy" pregnancy tests to satisfy "pee-on-a-stick" obsessions until it is really time to test (keeps you from spending WAY to0 much to support an addiction ~grin~)

Early Pregnancy Symptoms?

For everyone who thinks they are nuts for feeling "symptoms" 2-14 DPO, here's a little info for you to make you feel better. Bear with me, it may seem a little convoluted at first.

Before implantation, the blastocyst secretes specific substances that enhance endometrial receptivity. Successful implantation requires precise synchronization between blastocyst development and endometrial maturation. The early embryo and its surrounding cumulus cells secrete detectable estradiol and progesterone well before the time of implantation.

Conceptus-secreted progesterone may itself affect tubal motility as the conceptus is carried to the uterus. Progesterone, by action mediated through catecholamines and prostaglandins, is believed to relax utero-tubal musculature. Moreover, progesterone is thought to be important in tubal-uterine transport of the embryo to the uterine cavity, since receptors for progesterone are found in highest concentrations in the mucosa of the distal one third of the fallopian tube.

Estradiol, also secreted by these structures, may balance the progesterone effect so as to maintain the desired level of tubal motility and tone. Progesterone antagonizes estrogen-augmented uterine blood flow through depletion of estrogen receptors in the cytoplasm.

So, Estradiol and progesterone begins to elevate at conception, not implantation. On to the next point.....

Human chorionic gonadotropin (hCG) messenger ribonucleic acid (mRNA) is detectable in the blastomeres of 6- to 8-cell embryos; however, it is not detectable in blastocyst culture media until the 6th day. After implantation is initiated, hCG is detectable in maternal serum. However, due to the absence of direct vascular communication, secretion of hCG into the maternal circulation is initially limited.

Thus, during the process of implantation the embryo is actively secreting hCG, which can be detected in maternal serum as early as the 8th day after ovulation. The primary role of hCG is to prolong the biosynthetic activity of the corpus luteum, which allows continued progesterone production and maintenance of the gestational endometrium. As implantation progresses, the conceptus continues to secrete hCG and other pregnancy-related proteins, and resumes detectable steroid production.

HCG is what causes your HPT to show "positive" and will not begin to circulate in your system until implantation is initiated. Remember though, your estradiol and progesterone will begin to elevate at conception.

Okay .....onto the next point.

No one knows for certain exactly what causes nausea/vomiting "morning sickness" in pregnancy but a stong case has been made implicating progesterone, estrogen, and HCG or any combination of all three.

Progesterone and estrogen have both been listed as the cause for sore breasts and progesterone has been cited as the cause for extreme fatigue.

SO, people who say they started having sympoms a day or so after O are not crazy. Some people's bodies are more sensitive to changes than others. Remember, progesterone and estrogen start to rise at conception so some people may very well experience increased temps, nausea, vomiting, fatigue, and sore breasts.

Fertility Testing-Normal Lab Values

Lutenizing Hormone (LH)
Follicular Phase (day two or three): <7miu/ml
Day of LH Surge: >15mIU/ml

Follicle Stimulating Hormone (FSH)
Follicular Phase: <13miu/ml
Day of LH Surge: >15 mIU/ml

Estradiol
Day of LH Surge: >100 pg/ml
Mid Luteal Phase (seven days after O): >60 pg/ml

Progesterone
Day of LH Surge: <1.5 ng/ml
Mid Luteal Phase >15 ng/ml

Prolactin: <25 ng/ml

Thyroid Stimulating Hormone (TSH): 0.4 to 3.8 uIU/ml

Free T3: 1.4 to 4.4 pg/ml

Free Thyroxine (T4): 0.8 to 2.0 ng/dl

Total Testosterone: 6.0 to 89 ng/dl

Free Testosterone: 0.7 to 3.6 pg/ml

DHEAS: 35 TO 430 UG/DL

Androstenedione: 0.7 to 3.1 ng/ml

Aggressive Conception Plan

Begin BBT at CD1 and then:

CD 3:
Baseline US, Labs: FSH, estradiol, Prolactin, Thyroid Stimulating Hormone (TSH), Free T3, Free Thyroxine (T4), Total Testosterone, Free Testosterone, DHEAS and Androstenedione. You could hold off on the adrogen panel to see what your LH/FSH ratio is but I would just go ahead and get it. I might also go ahead and add a HgbA1C and GTT depending on the circumstances.

CD 7:
Begin OPK, saliva microscope, fertility monitor, disposable ferning strips. Begin checking cervical position/mucus/texture. Continue all of these throughout the entire cycle.

Day of LH surge:
US to assess the thickness of the endometrium (lining of the uterus), monitor follicle development and assess the condition of the uterus and ovaries. Labs: LH, FSH, Estradiol, Progesterone. Repeat US 2-3 days after LH surge to rule out lutenized unruptured follicle (LUF) syndrome---a situation in which eggs ripen but do not release from the follicle. This is a subtle form of female infertility and a bit difficult to diagnose.

From LH surge until 2 days after O:
Serial ultrasounds to monitor follicles

Seven days after O:
Estradiol and progesterone

After I had all of the test results and a full cycle of documented information (temps, opks, CP, CM, etc) then I would come up with a plan of where to go from there.

New Information Only Blog!

This is a public blog for me to post "snippets" of information for people trying to conceive. Read this part very carefully please:

**** I AM NOT A DOCTOR ****

Hmmm, I wonder if that was clear enough. This is just information I thought would be helpful to people.

Okay, rules of the blog since it's public and listed in the blogger directory.

1) You can only post a comment as a registered user

2) Comments will only be available to view after I review them (because people can be asses). For the sake of keeping the blog as informational as I can, I will only publish questions --ones that I have an answer for and have not addressed before in the blog.

3) If you post something nasty it will get deleted and I will pray that God holds off blessing you with a child until you are no longer an asshole. (No, I do not think God blesses people on my say so but that won't stop me from throwing in a word on my next prayer!)

4) It is my blog and I will mention God/Jesus if I want and I will say asshole if I want. No I'm not being disrespectful of other's belief systems; believe what you want but if you want to read a blog about it-start your own.

5) If you're going to get your knickers in a knot over any of the above, go find another blog or click the red X in the top right hand corner of your screen.

6) All of that looks pretty harsh......I'm sorry it looks that way because I'm not really like that but after a few "nastygrams" I thought I better kinda lay it all out there.

Having said all of the mean stuff let me add this: Good luck to all trying to conceive and I hope yours prayers are answered soon!


...."for verily I say unto you, If ye have faith as a grain of mustard seed, ye shall say unto this mountain, Remove hence to yonder place; and it shall remove; and nothing shall be impossible unto you." Matthew 17:20